40+ Mastiff puppies for sale from ethical breeders near Greenville, SC
Raised by Karen L.
Looking Glass English Mastiffs · 25 miles away from Greenville, SC
We absolutely love Mastiffs, and we aim to produce healthy and exceptional puppies that will thrive in their future homes.
Willow, mom
Grantham, dad
GSRaised by Gary S.
Two Ponds Mastiffs · 30 miles away from Greenville, SC
We here at Two Ponds Mastiffs have been raising and loving mastiffs for nearly 30 years.
Male, reserved
Male, reserved
Raised by Katie B.
Sunrise Mastiffs · 40 miles away from Greenville, SC
We’re a small, family oriented breeding program that focuses on exceptional temperament & health.
Female, available
Male, available
Raised by Danielle P.
Little Mountain Mastiffs · 77 miles away from Greenville, SC
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
1 owner review
We’ve screened nearly every breeder in the U.S.—only 1 in 5 meet our standard for responsible breeding.
Male, reserved
Male, reserved
Raised by Karen W.
Lakeside English Mastiffs of Georgia and North Carolina · 94 miles away from Greenville, SC
Our high-quality puppies are the result of extensive research and thorough care for our outstanding dogs and puppies.
1 owner review
Dakota or Kota, dad
Esther, mom
Raised by Suzie F.
Celtic's Mastiffs · 119 miles away from Greenville, SC
I've had the honor to be owned by Mastiffs I've bred for many, many years. I can't imagine my life without them by my side.
Zoe, mom
Raised by Cindy R.
Halfway Creek Farms · 135 miles away from Greenville, SC
I raise Mastiffs with health, care, and temperament in mind, and am part of Good Dog's vetted network.
Naughty, mom
Sura, mom
Raised by Lucy S.
ScottsCreek Mastiffs · 136 miles away from Greenville, SC
We work hard to produce healthy, well-rounded Mastiff puppies that will make others as happy as our dogs have made us!
Samson, dad
Raised by David H.
Hillside Mastiffs · 157 miles away from Greenville, SC
We breed high-quality mastiff/Great Dane puppies. We love what we do and are committed to producing well-bred, healthy puppies.
Bjorn, mom
Fenris, mom
Raised by Lacy S.
Storytime Mastiffs & Bulldogs · 164 miles away from Greenville, SC
At Storytime Mastiffs & Bulldogs we pride ourselves on breeding healthy puppies while also focusing on type and temperament.
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Dakota, mom
Raised by Kim R.
Titan Mastiffs · 179 miles away from Greenville, SC
We raise our puppies with total care and attention so they can become well-socialized and loving additions to their forever homes.
1 owner review
Tric, dad
Ash, mom
Raised by Jennifer G.
Jennifer s Appalachian Mountain Mastiffs · 200 miles away from Greenville, SC
We understand the responsibility of purposefully breeding in order to do better for the breed and the families that love them!
Raised by Diane G.
Sylvan Mastiffs · 219 miles away from Greenville, SC
Being a breeder is my passion, not my job. I love having the opportunity to share these wonderful companions with other families!
Male, reserved
Female, reserved
Raised by Jeana F.
Jeana's Rottweilers & English Mastiffs · 223 miles away from Greenville, SC
We work hard to produce healthy, well-rounded purebreds. Rottweiler & Mastiff puppies!
Raised by Angela C.
Sovereign Mastiffs · 231 miles away from Greenville, SC
We responsibly breed, raise, & socialize healthy pups so others can enjoy the gift of living life with a Mastiff!
Raised by Celeste G.
Liberty Mountain · 241 miles away from Greenville, SC
We are huge animal lovers and have a special place in our hearts for our dogs. We want to provide top-quality beloved companions.
Indy, mom
Oopsie, mom
Raised by Becky C.
Coopers Mastiffs & Duck Tollers · Drop-off to you
We built our program with care and intention in every step. We care deeply about the health and wellbeing of these breeds.
Apollo, dad
Roxie, mom
Raised by Maria B.
Stoneheart Mastiffs · Meet breeder for pickup
We do health testing and keep our dogs in tip top shape. They get expert vet care, great nutrition, and lots of love.
2 owner reviews
Willow, mom
Gabby, mom
Raised by Candy P.
Southern Oaks Kennel · Meet breeder for pickup
Our goal is to raise healthy, happy puppies to the breed standard for families to love and enjoy as pets or for show homes.
1 owner review
Susie, mom
Kato, dad
Raised by Kristi L.
Kentucky Mastiffs · Meet breeder for pickup
I offer top-quality Mastiff puppies for families who share the same love and passion that I do for these lovely companions.
Male, reserved
Male, reserved
Raised by Reva T.
❤️ Thompson's Family Mastiffs ❤️ · Drop-off to you
We’re proud of the healthy, affectionate, and well-rounded puppies that we produce and raise so that others may know their love.
3 owner reviews
Juno, mom
Raised by Carolyn W.
Nytewind Mastiffs · Drop-off to you
I breed Mastiffs to improve the quality of the breed and to offer service dogs to people like myself. I love my dogs & what I do!
NALA, mom
DMRaised by Domenic M.
Hooligan Mastiffs · Drop-off to you
We hold ourselves to high standards for the integrity of our program. All of our puppies are socialized, nurtured, and loved!
1 owner review
Elia, mom
Howie, dad
SCRaised by Sarah C.
SMC Mastiffs / Muddy Boots Cocker Spaniels and Cockapoos · Meet breeder for pickup
We breed quality health tested dogs that have excellent temperaments. Our goal is to produce amazing family members!!
Watcher, mom
Darth, dad
ESRaised by Erin S.
Kasota Farm · Drop-off to you
Our dogs are bred for health, temperament, and ability. We strive to produce beautiful and versatile beloved companions.
Zena, mom
Boogieman, dad
Raised by Brian J.
MLJ Mastiffs Florida · Drop-off to you
We breed to enhance the breed with quality bone structure for size and genetics for health. We take great pride in our work!
Kia, mom
Raised by Lori C.
J and L Farms Mastiff’s · Drop-off to you
We offer AKC Championship Bloodline English Mastiffs we focus on healthy well breed dogs with good temperaments.
Raised by Alison R.
AKA Shih Tzu · Meet breeder for pickup
My program is built upon a foundation of love, admiration, and respect for the Shih Tzu and Mastiff breeds.
Kemper, dad
Shadow, mom
Raised by Colleen L.
Round Town Mastiffs · Meet breeder for pickup
We're new breeders starting a small program. We hope to help provide families with quality puppies as we continue to learn & grow!
Nell, mom
Tucker, dad
Raised by Julie A.
Beaver Creek Mastiffs · Drop-off to you
Our Mastiffs are raised with lots of love and pride. Making sure we provide you with the absolute best Mastiff puppy available.
Page, mom
Page, mom
Raised by Cathy I.
Cedarhills · Drop-off to you
We offer top quality pups to loving homes
1 owner review
Zeus, dad
Hera, mom
CBRaised by Chandler B.
Old Moonshine Mastiffs · Meet breeder for pickup
We are committed to always responsibly breeding with the best interest of our puppies’ health and longevity at the forefront.
Artemis, mom
Raised by Monica B.
Hickory Creek Mastiffs · Drop-off to you
We breed fully health tested, AKC championed Mastiffs that represent the breed standard in appearance, structure, and temperament.
Big Guy, dad
ADRaised by Angela D.
Bittersweet Lane Mastiffs · Meet breeder for pickup
We offer high-quality Mastiff puppies to show and companion homes. We breed for health, temperament, and conformation.
Alisha, mom
Tyson, dad
GSRaised by Gary G. S.
Gary Schneider’s Mastiffs · Meet breeder for pickup
Our dogs and pups are raised in our home and are loved as family. We strive to produce high-quality show prospects and companions.
Raised by Justine C.
Murphy's Landing Mastiffs · Meet breeder for pickup
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
Raised by Becky W.
Large Paw Masiffs · Meet breeder for pickup
Our Mastiff pups are home-raised. We put a lot of care into socializing them so they can transition easily into their new lives.
Tobias, dad
Sassi, mom
Raised by Amber W.
Weiler’s Gentle Giants · Drop-off to you
We hold ourselves to the highest standard when it comes to our dogs and our policies. We take responsible breeding very seriously.
- SW
Raised by Sherry W.
Sherry's German Shepherds and Mastiffs · Meet breeder for pickup
We are pet owners first and foremost. All of our puppies are raised as members of our family until they’re ready to join yours.
- NG
Raised by Nicole G.
Legacy Farms · Meet breeder for pickup
We are lifelong dog enthusiasts, and we’re excited to share our passion and purpose with others through our breeding program.
Zuko, dad
Zucci, mom
JCRaised by Jordan C.
Big Z English Mastiff · Meet breeder for pickup
As conscientious breeders, we are proud of the loving, smart, beautiful, and sound puppies we’re able to provide for others.
Female, reserved
Raised by Angela A.
Angela's Mastiffs · Drop-off to you
We have both AKC and CKC registered English Mastiffs and we are now also breeding the Daniff. The best of both giant breeds!
6 owner reviews
Related breeds
Mastiff
Buyer’s Guide
Nationally, prices usually range from $2,500 to $3,500. While it may cost more up front, starting with a healthy puppy can help you avoid costly issues later. These ranges reflect the care behind responsible breeding and offer a reliable view of what ethical breeding really costs.
About the Mastiff
The Mastiff is an ancient breed that is well-mannered and fearless. With proper socialization, this massive breed is a noble and calm companion.
Moderate energy
Energy level
Easy coat care
Coat care
High shedding
Shedding
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Frequently asked questions
What is the average cost of Mastiff puppies in Greenville, SC?
Prices may vary based on the breeder and individual puppy for sale in Greenville, SC. On Good Dog, Mastiff puppies in Greenville, SC range in price from $2,900 to $3,400. We recommend speaking directly with your breeder to get a better idea of their price range.
Do Mastiff puppies in Greenville, SC shed?
Mastiff puppies in Greenville, SC are a high shedding breed. However, it's possible that a dog's level of shedding may vary by individual puppy.
What is the average size range of Mastiff puppies in Greenville, SC?
The expected weight range for male Mastiff puppies in Greenville, SC is 160 to 230 pounds. The expected weight range for female Mastiff puppies in Greenville, SC is 120 to 170 pounds. Because size and weight may vary based on individual dogs, your dog may be outside of that range.
What is the average lifespan for Mastiff puppies in Greenville, SC?
The average lifespan for Mastiff puppies in Greenville, SC is 6 to 10 years of age.
Can I adopt a Mastiff from a rescue or shelter?
On Good Dog, you can search for Mastiff puppies or dogs in rescues and shelters near Greenville, SC. Adopting a Mastiff from a shelter or rescue in Greenville, SC is generally less expensive than buying a puppy from a breeder with ethical practices. Across the United States, there are dedicated rescues that specialize in specific breeds and may even help transport a Mastiff dog to you in Greenville, SC from another part of the country. Although it can be more cost-effective, adopting the exact breed you're looking for is typically more difficult than working with a responsible breeder. Learn more about adopting a dog from a shelter or rescue.
About Good Dog
About Good Dog
Good Dog is your trusted partner for finding Mastiff puppies for sale near Greenville, SC. Our vetted network of responsible Mastiff breeders makes it easy to search listings, connect directly, and ask questions — all in one safe, protected place. Work directly with breeders you can trust and complete payments securely through Good Dog, so you can bring home your Mastiff puppy with confidence.