40+ Mastiff puppies for sale from ethical breeders near Cape Girardeau, MO
Page, mom
Page, mom
Raised by Cathy I.
Cedarhills · 111 miles away from Cape Girardeau, MO
We offer top quality pups to loving homes
1 owner review
Alisha, mom
Tyson, dad
GSRaised by Gary G. S.
Gary Schneider’s Mastiffs · 112 miles away from Cape Girardeau, MO
Our dogs and pups are raised in our home and are loved as family. We strive to produce high-quality show prospects and companions.
Juno, mom
Raised by Carolyn W.
Nytewind Mastiffs · 123 miles away from Cape Girardeau, MO
I breed Mastiffs to improve the quality of the breed and to offer service dogs to people like myself. I love my dogs & what I do!
Raised by Alison R.
AKA Shih Tzu · 139 miles away from Cape Girardeau, MO
My program is built upon a foundation of love, admiration, and respect for the Shih Tzu and Mastiff breeds.
We’ve screened nearly every breeder in the U.S.—only 1 in 5 meet our standard for responsible breeding.
Raised by Caleb W.
Ozark Mountain Mastiffs · 158 miles away from Cape Girardeau, MO
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
Dolly, mom
Raised by JOSEPH T.
Trindade Mastiffs · 174 miles away from Cape Girardeau, MO
We are a small family breeder focused on bettering the mastiff breed.
Betty, mom
Louise, mom
Raised by Tim S.
Ozark Mountain Mastiffs · 175 miles away from Cape Girardeau, MO
We are a small scale breeder who focuses on Mastiffs only.
29 owner reviews
Female, reserved
Female, reserved
Raised by Elizabeth R.
Riggins Mastiffs and Danes · 175 miles away from Cape Girardeau, MO
We’re devoted to ensuring there are healthy Mastiffs for others to enjoy by responsibly growing this incredible breed.
Kaia, mom
Raised by Madison O.
M&M Aussie's & Mastiff's · 188 miles away from Cape Girardeau, MO
Faceb page with more information! M&M Aussies Of Monroe City ( trying to change the name since moved and added mastiffs)
Female, available
Female, available
Raised by Karin C.
Hug-A-Mug Mastiffs · 198 miles away from Cape Girardeau, MO
I'm a preservationist breeder and passionate about the English Mastiff. I've been showing and breeding healthy litters since 1978.
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Raised by Celeste G.
Liberty Mountain · 205 miles away from Cape Girardeau, MO
We are huge animal lovers and have a special place in our hearts for our dogs. We want to provide top-quality beloved companions.
Kato, dad
Susie, mom
Raised by Kristi L.
Kentucky Mastiffs · 213 miles away from Cape Girardeau, MO
I offer top-quality Mastiff puppies for families who share the same love and passion that I do for these lovely companions.
Raised by Diane G.
Sylvan Mastiffs · 214 miles away from Cape Girardeau, MO
Being a breeder is my passion, not my job. I love having the opportunity to share these wonderful companions with other families!
King, mom
TPRaised by Theresa P.
Theresa's Mastiffs · 230 miles away from Cape Girardeau, MO
We are pet owners first and foremost. All of our puppies are raised as members of our family until they’re ready to join yours.
- DC
Raised by David C.
David's Mastiffs · 230 miles away from Cape Girardeau, MO
We are lifelong dog enthusiasts, and we’re excited to share our passion and purpose with others through our breeding program.
Minni, mom
Raised by Michele & Andy P.
Parbury Place Mastiffs · 232 miles away from Cape Girardeau, MO
We love the mellow temperament of these gentle giants and are excited to help other families find the perfect pup for their home.
Booker, mom
Raised by Shari S.
Bowtied Lickers · 235 miles away from Cape Girardeau, MO
We focus on intentional breeding so that we can produce quality puppies that are excellent representations of the standard.
Huey, dad
Ava, mom
Raised by Elesha P.
Mama’s Mastiffs · Meet 61 miles away from Cape Girardeau, MO
Specializing in quality, DNA health tested, OFA certified English Mastiffs since 2006
5 owner reviews
Zucci, mom
Zuko, dad
JCRaised by Jordan C.
Big Z English Mastiff · Meet breeder for pickup
As conscientious breeders, we are proud of the loving, smart, beautiful, and sound puppies we’re able to provide for others.
Vegas, mom
Calisto, dad
Raised by Julie A.
Beaver Creek Mastiffs · Drop-off to you
Our Mastiffs are raised with lots of love and pride. Making sure we provide you with the absolute best Mastiff puppy available.
Samson, dad
Raised by David H.
Hillside Mastiffs · Meet breeder for pickup
We breed high-quality mastiff/Great Dane puppies. We love what we do and are committed to producing well-bred, healthy puppies.
Raised by Angela C.
Sovereign Mastiffs · Meet breeder for pickup
We responsibly breed, raise, & socialize healthy pups so others can enjoy the gift of living life with a Mastiff!
Fenris, mom
Knuckles, mom
Raised by Lacy S.
Storytime Mastiffs & Bulldogs · Drop-off to you
At Storytime Mastiffs & Bulldogs we pride ourselves on breeding healthy puppies while also focusing on type and temperament.
Watcher, mom
Darth, dad
ESRaised by Erin S.
Kasota Farm · Drop-off to you
Our dogs are bred for health, temperament, and ability. We strive to produce beautiful and versatile beloved companions.
Elia, mom
Nymeria, mom
SCRaised by Sarah C.
SMC Mastiffs / Muddy Boots Cocker Spaniels and Cockapoos · Meet 215 miles away from Cape Girardeau, MO
We breed quality health tested dogs that have excellent temperaments. Our goal is to produce amazing family members!!
- DL
Raised by Deborah L. Hatch L.
Deborah's Mastiffs · Meet breeder for pickup
We care deeply about the Mastiff, and we breed to help ensure the health and future of these wonderful dogs.
Dakota or Kota, dad
Esther, mom
Raised by Suzie F.
Celtic's Mastiffs · Meet breeder for pickup
I've had the honor to be owned by Mastiffs I've bred for many, many years. I can't imagine my life without them by my side.
Kia, mom
Raised by Lori C.
J and L Farms Mastiff’s · Drop-off to you
We offer AKC Championship Bloodline English Mastiffs we focus on healthy well breed dogs with good temperaments.
Male, reserved
Male, reserved
Raised by Karen W.
Lakeside English Mastiffs of Georgia and North Carolina · Drop-off to you
Our high-quality puppies are the result of extensive research and thorough care for our outstanding dogs and puppies.
1 owner review
- LF
Raised by LaDonna F.
North Mississippi Mastiffs · Meet breeder for pickup
We’re so excited to be able to help families experience the longtime loyalty of welcoming a new puppy into their lives!
Apollo, dad
Roxie, mom
Raised by Maria B.
Stoneheart Mastiffs · Meet breeder for pickup
We do health testing and keep our dogs in tip top shape. They get expert vet care, great nutrition, and lots of love.
2 owner reviews
Ginger, mom
Carmella, mom
Raised by Candie K.
Faith Mastiffs · Drop-off to you
We value responsible breeding practices and want to do our part to ensure the Mastiff will continue to thrive.
Female, reserved
Male, reserved
Raised by Karen P.
Kharisma Mastiffs · Meet breeder for pickup
Our goal is to ensure every dog from our program is set up to live a happy and healthy life and is prepared for its future role.
BARBIE, mom
New litter
Raised by Diana B.
Puppy Paradise: English Mastiff Puppies & Standard Goldendoodle Puppies · Drop-off to you
Our dogs are our beloved companions. We love to raise our puppies so they have the tools to be well-rounded, loved family members.
2 owner reviews
Female, reserved
Female, reserved
Raised by Tim L.
Flanders Kennels LLC · Drop-off to you
Small, nonprofit breeder of health tested, working farmstead Boerboels and companion Mastiffs. Also help giant breed dogs in need.
Big Guy, dad
ADRaised by Angela D.
Bittersweet Lane Mastiffs · Meet breeder for pickup
We offer high-quality Mastiff puppies to show and companion homes. We breed for health, temperament, and conformation.
Female, available
Female, available
Raised by Jazz W.
FrontlineK9 Boarding & Training LLC · Drop-off to you
All our dogs are bred with the standard of bettering the overall health of the breed and to create a healthy reliable Mastiffs.
Obama, dad
Lady, mom
Raised by Alison B.
Eagle Mastiffs · Meet breeder for pickup
Our mission is to raise healthy, happy, adorable Mastiff puppies and connect loving families with their new best friend!
1 owner review
Kemper, dad
Shadow, mom
Raised by Colleen L.
Round Town Mastiffs · Meet breeder for pickup
We're new breeders starting a small program. We hope to help provide families with quality puppies as we continue to learn & grow!
Raised by Justine C.
Murphy's Landing Mastiffs · Meet breeder for pickup
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
Raised by Becky W.
Large Paw Masiffs · Meet breeder for pickup
Our Mastiff pups are home-raised. We put a lot of care into socializing them so they can transition easily into their new lives.
- LF
Raised by Leah F.
Cub Lake Pyrenees Mastiff · Meet breeder for pickup
Our family provides your family with extremely well tempered and a very healthy puppy! Each puppy goes home with a puppy care bag.
Related breeds
Mastiff
Buyer’s Guide
Nationally, prices usually range from $2,500 to $3,500. While it may cost more up front, starting with a healthy puppy can help you avoid costly issues later. These ranges reflect the care behind responsible breeding and offer a reliable view of what ethical breeding really costs.
About the Mastiff
The Mastiff is an ancient breed that is well-mannered and fearless. With proper socialization, this massive breed is a noble and calm companion.
Moderate energy
Energy level
Easy coat care
Coat care
High shedding
Shedding
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Frequently asked questions
What is the average cost of Mastiff puppies in Cape Girardeau, MO?
Prices may vary based on the breeder and individual puppy for sale in Cape Girardeau, MO. On Good Dog, Mastiff puppies in Cape Girardeau, MO range in price from $1,850 to $4,250. We recommend speaking directly with your breeder to get a better idea of their price range.
Do Mastiff puppies in Cape Girardeau, MO shed?
Mastiff puppies in Cape Girardeau, MO are a high shedding breed. However, it's possible that a dog's level of shedding may vary by individual puppy.
What is the average size range of Mastiff puppies in Cape Girardeau, MO?
The expected weight range for male Mastiff puppies in Cape Girardeau, MO is 160 to 230 pounds. The expected weight range for female Mastiff puppies in Cape Girardeau, MO is 120 to 170 pounds. Because size and weight may vary based on individual dogs, your dog may be outside of that range.
What is the average lifespan for Mastiff puppies in Cape Girardeau, MO?
The average lifespan for Mastiff puppies in Cape Girardeau, MO is 6 to 10 years of age.
Can I adopt a Mastiff from a rescue or shelter?
On Good Dog, you can search for Mastiff puppies or dogs in rescues and shelters near Cape Girardeau, MO. Adopting a Mastiff from a shelter or rescue in Cape Girardeau, MO is generally less expensive than buying a puppy from a breeder with ethical practices. Across the United States, there are dedicated rescues that specialize in specific breeds and may even help transport a Mastiff dog to you in Cape Girardeau, MO from another part of the country. Although it can be more cost-effective, adopting the exact breed you're looking for is typically more difficult than working with a responsible breeder. Learn more about adopting a dog from a shelter or rescue.
About Good Dog
About Good Dog
Good Dog is your trusted partner for finding Mastiff puppies for sale near Cape Girardeau, MO. Our vetted network of responsible Mastiff breeders makes it easy to search listings, connect directly, and ask questions — all in one safe, protected place. Work directly with breeders you can trust and complete payments securely through Good Dog, so you can bring home your Mastiff puppy with confidence.