40+ Great Dane puppies for sale from ethical breeders near Cape Girardeau, MO
Kaya, mom
Raised by Taylor R.
Double R Danes · 49 miles away from Cape Girardeau, MO
At Double R Danes, we are dedicated to offering quality puppies with amazing temperament, conformation, and health above all!
Female, available
Raised by DAYSHA B.
Breken Great Danes · 57 miles away from Cape Girardeau, MO
We are huge animal lovers and have a special place in our hearts for our dogs. We want to provide top-quality beloved companions.
3 owner reviews
Female, reserved
Male, reserved
SRRaised by Stephanie R.
Reagan’s Danes · 78 miles away from Cape Girardeau, MO
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
Juliet, mom
Nova, mom
Raised by Vicki M.
Vicki's Danes and frenchies · 87 miles away from Cape Girardeau, MO
We’re devoted to ensuring there are healthy puppies for others to enjoy and we do so by responsibly growing this incredible breed.
We’ve screened nearly every breeder in the U.S.—only 1 in 5 meet our standard for responsible breeding.
Raised by Keri W.
Southern Grace Great Danes · 98 miles away from Cape Girardeau, MO
Our mission is to raise healthy, happy, adorable Great Dane puppies and connect loving families with their new best friends!
Marina, mom
Loretta, mom
Raised by Jason D.
Legado Danes · 103 miles away from Cape Girardeau, MO
We breed and show top-quality dogs. Our heavy involvement in the show world speaks to the standards that we breed our dogs by.
Benelli, mom
Bijou, mom
Raised by Eleesha L.
A Spot Of Blue Great Danes/ Marshland Corgis · 108 miles away from Cape Girardeau, MO
We are A Spot Of Blue Great Danes/Marshland Corgis. We breed quality, health tested, Great Danes and Show prospect Pembroke Corgis
1 owner review
Female, available
Female, available
Raised by Kala F.
Show Me Great Danes and Basset Hounds · 115 miles away from Cape Girardeau, MO
Midwest Breeder, with focus on personal relationships with adopters, puppies raised in-home, and healthy breeding practices.
1 owner review
Raised by Kelsey F.
K.C. Kennels · 127 miles away from Cape Girardeau, MO
We take great pride in breeding to produce pups that are the total package.
Chaos, mom
Malcolm, dad
Raised by Emily P.
Phantasm Farms · 129 miles away from Cape Girardeau, MO
We are a small, intentional Great Dane breeder devoted to preserving the breed’s gentle nature, health, and structure.
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Diablo, dad
Nala, mom
Raised by Michelle P.
Babydoll Bullies & Danes · 133 miles away from Cape Girardeau, MO
Our Great Danes come from European Champion bloodlines. We OFA test our dams & sires
Raised by Regina A.
Weeping willow Danes · 135 miles away from Cape Girardeau, MO
Our dogs are our beloved companions. We care deeply about this breed and are proud to be responsible Great Dane breeders.
Raised by Linda S.
Owl Valley Danes · 135 miles away from Cape Girardeau, MO
We are huge animal lovers and have a special place in our hearts for our dogs. We want to provide top-quality beloved companions.
- KM
Raised by Karen M.
Danemark Danes · 135 miles away from Cape Girardeau, MO
We focus on intentional breeding so that we can produce quality puppies that are excellent representations of the standard.
Strait, dad
Roper, mom
Raised by Christina S.
Mill Iron S Great Danes · 135 miles away from Cape Girardeau, MO
We’re proud of the healthy, affectionate, and behaviorally well-rounded puppies we raise for other families to love!
Bodhi, dad
Lucy, mom
Raised by Kayla L.
Oak View Danes · 135 miles away from Cape Girardeau, MO
We understand the responsibility of purposefully breeding in order to do better for the breed and the families that love them!
12 owner reviews
Male, reserved
Male, reserved
Raised by Michelle C.
Campbell Great Danes · 138 miles away from Cape Girardeau, MO
Puppies are raised in our home. They come from AKC champion bloodlines. Parent dogs are OFA tested. Puppies are AKC registered.
Female, available
Female, available
Raised by Lauren B.
Balthrop Bend Farms · 147 miles away from Cape Girardeau, MO
We raise quality and health tested AKC English Springer Spaniels and Great Danes.
4 owner reviews
Raised by Pam G.
Great Dane Ridge · 150 miles away from Cape Girardeau, MO
I strive to produce quality puppies for families that are structurally sound, healthy, intuitive and have wonderful temperaments.
Suri, mom
Raised by Megan T.
Megan Toeller · 152 miles away from Cape Girardeau, MO
Located in Memphis, TN, KDT Danes is a small preservation breeder with typically only 1 litter per year.
Female, reserved
Ashkelon, dad
Raised by Heather W.
Genai Great Danes · 155 miles away from Cape Girardeau, MO
Our name, Genai, means "the one whom everyone loves." We love our Danes, and we hope you will too’
1 owner review
Vera, mom
Levi, dad
Raised by Robin P.
Aidens Great Danes · 156 miles away from Cape Girardeau, MO
Our goal is to ensure every dog from our program is set up to live a happy and healthy life and is prepared for its future role.
Raised by Joyce G.
Liberty Danes · 175 miles away from Cape Girardeau, MO
Our goal is to ensure every dog from our program is set up to live a happy and healthy life and is prepared for its future role.
Freya, mom
Atlas, dad
Raised by Patricia R.
Trisha Self's Great Danes · 179 miles away from Cape Girardeau, MO
We breed high-quality Great Dane. We love what we do and are committed to producing well-bred, healthy puppies for loving homes.
Bruce, dad
Freyja, mom
Raised by Lila T.
Moonwater Danes · 184 miles away from Cape Girardeau, MO
We love to responsibly raise and train our puppies so they have the tools to be well-rounded, beloved family members.
Raised by Jodi L.
Borealis Danes · 186 miles away from Cape Girardeau, MO
I offer well-tempered, health-tested Great Danes for loving homes. They are happy, intelligent, and cute as can be!
Male, reserved
Male, reserved
Raised by Glenda T.
T3 Enchanted Forrest Danes · 189 miles away from Cape Girardeau, MO
We are a small scale family owned/operated European Great Dane Breeder.
Burger, dad
Minnie, mom
HMRaised by Hope M.
Hope's Danes · 193 miles away from Cape Girardeau, MO
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
- ER
Raised by Emily R.
Emily Ramsey's Great Danes · 194 miles away from Cape Girardeau, MO
I offer top-quality Great Danes puppies with a focus on health, color, conformation, and temperament. My goal to better the breed!
Raised by Terrie R.
Terrie Rhoden Kirkland · 194 miles away from Cape Girardeau, MO
As a responsible breeder of Great Danes, I meet Good Dog's standards for health, care, and ethical practices.
Emma, mom
Raised by Rebecca A.
Acres Verdes Danes · 197 miles away from Cape Girardeau, MO
I offer quality Great Dane puppies with a focus on health, form, and function. I believe quality is more important than quantity.
Male, reserved
Female, reserved
Raised by Dustin & Karen M.
7Sisters Great Danes · 203 miles away from Cape Girardeau, MO
We value responsible breeding practices and want to do our part to ensure the Great Dane breed will continue to thrive.
Raised by Angela W.
Spring Creek Danes · 205 miles away from Cape Girardeau, MO
Our dogs are bred to have top qualities that all families want in their puppies, such as compassion, patience, and love!
- KW
Raised by Krystal W.
Krystal’s Glam Puppies · 205 miles away from Cape Girardeau, MO
Our mission is to raise healthy, happy, adorable Great Dane puppies and connect loving families with their new best friend!
- SH
Raised by Sarah H.
Wilder Mountain Danes · 205 miles away from Cape Girardeau, MO
Each puppy is bred, raised, and loved indoors to ensure health, happiness, and harmony at the start of its life.
Belle, mom
Raised by Genile D.
Dennison's Danes · 210 miles away from Cape Girardeau, MO
My focus is on maintaining the breed standard by raising structurally sound and correct puppies with correct temperments.
Duke, dad
Duchess, mom
Raised by Robert B.
Blue Dane Ridge · 214 miles away from Cape Girardeau, MO
We offer Great Dane puppies from our AKC registered adults about once a year. We raise these babies in our home.
1 owner review
Kylo, dad
Rey, mom
Raised by Kristen I.
Galactic Danes · 218 miles away from Cape Girardeau, MO
All of our puppies are bred, raised, and loved indoors to produce happy, healthy pets for those seeking the best family companion!
Male, reserved
Male, reserved
AMRaised by Anna M.
Delta Danes · 219 miles away from Cape Girardeau, MO
We work hard to produce healthy, well-rounded Great Dane puppies that will make others as happy as our dogs have made us!
Duke, dad
Love, mom
JBRaised by Julia B.
Bentleys Danes · 221 miles away from Cape Girardeau, MO
Every puppy I raise is adored as part of our family from birth. Our puppies will complete your home, your family, and your heart!
Dilley, dad
Reenie, mom
Raised by Danielle E.
S&D's Gentle Giants · 222 miles away from Cape Girardeau, MO
All of our dogs are loved as family members. We cherish our puppies from birth up until they leave our arms to snuggle into yours!
Male, reserved
Male, reserved
Raised by Kelly M.
Dusty Dream Danes · 222 miles away from Cape Girardeau, MO
We are committed to always responsibly breeding with the best interest of our puppies’ health and longevity at the forefront.
Related breeds
Great Dane
Buyer’s Guide
Nationally, prices usually range from $2,000 to $3,000. While it may cost more up front, starting with a healthy puppy can help you avoid costly issues later. These ranges reflect the care behind responsible breeding and offer a reliable view of what ethical breeding really costs.
About the Great Dane
This dog is magnificent, combining great size and commanding appearance with a surprising amount of gentleness and, yes, goofiness. Learn more
Moderate Energy
Energy level
Minimal Maintenance
Grooming
Average Trainability
Trainability
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Frequently asked questions
What is the average cost of Great Dane puppies in Cape Girardeau, MO?
Prices may vary based on the breeder and individual puppy for sale in Cape Girardeau, MO. On Good Dog, Great Dane puppies in Cape Girardeau, MO range in price from $1,500 to $2,500. We recommend speaking directly with your breeder to get a better idea of their price range.
Is Great Dane in Cape Girardeau, MO a high shedding breed?
Great Dane puppies in Cape Girardeau, MO are a moderate shedding breed. However, it's possible that a dog's level of shedding may vary by individual puppy.
How long do Great Dane puppies in Cape Girardeau, MO live on average?
Great Dane puppies in Cape Girardeau, MO may live on average between 7 to 10 years.
Do Great Dane need a lot of exercise in Cape Girardeau, MO?
Great Dane puppies in Cape Girardeau, MO tend to have moderate energy. Typically, dogs with a moderate energy level may require around 30 to 60 minutes per day of physical activity, though individual dogs may fall outside that range.
Can I adopt a Great Dane from a rescue or shelter?
On Good Dog, you can search for Great Dane puppies or dogs in rescues and shelters near Cape Girardeau, MO. Adopting a Great Dane from a shelter or rescue in Cape Girardeau, MO is generally less expensive than buying a puppy from a breeder with ethical practices. Across the United States, there are dedicated rescues that specialize in specific breeds and may even help transport a Great Dane dog to you in Cape Girardeau, MO from another part of the country. Although it can be more cost-effective, adopting the exact breed you're looking for is typically more difficult than working with a responsible breeder. Learn more about adopting a dog from a shelter or rescue.
About Good Dog
About Good Dog
Good Dog is your trusted partner for finding Great Dane puppies for sale near Cape Girardeau, MO. Our vetted network of responsible Great Dane breeders makes it easy to search listings, connect directly, and ask questions — all in one safe, protected place. Work directly with breeders you can trust and complete payments securely through Good Dog, so you can bring home your Great Dane puppy with confidence.