40+ Great Dane puppies for sale from ethical breeders near Florence, SC
Zuber, mom
Raised by Marisa
Double Doo Ranch · 22 miles away from Florence, SC
We love these pups! We love Great Danes, in general. Smart, loyal and loving, we know you’ll love them too!
Patriot, dad
Carolina, mom
Raised by Chris B.
Blackmon Family Danes · 35 miles away from Florence, SC
Having a Great Dane is not like having a pet, it is a whole way of life that we love very much! Our dogs are our pride and joy!
Male, reserved
Male, reserved
Raised by Sarah A.
Outback Danes · 51 miles away from Florence, SC
Raising Quality, AKC Registered Great Danes from Health Tested Parents with a Splash of Color.
Female, available
Raised by Jennifer D.
Days Danes · 51 miles away from Florence, SC
We offer top quality, family pets with a focus on health and temperament.
We’ve screened nearly every breeder in the U.S.—only 1 in 5 meet our standard for responsible breeding.
Buddy, dad
Cowboy, dad
Raised by elizabeth l.
DoodleDandy & Danes · 64 miles away from Florence, SC
Having a dog in our lives is such a blessing. We find so much fulfillment in providing that same companionship to other homes!
2 owner reviews
- TH
Raised by Terri H.
Triple D Danes · 75 miles away from Florence, SC
Our mission is to raise healthy, happy, adorable Great Dane puppies and connect loving families with their new best friend!
Tyga, dad
Honey, mom
Raised by Ryley N.
Rivercliff Danes · 78 miles away from Florence, SC
We breed high-quality puppies. We love what we do and are committed to producing well-bred, healthy puppies for loving homes.
Raised by Sue B.
Sanctuary Great Danes · 79 miles away from Florence, SC
We offer top quality, loving family pets and show dogs with a focus on health and temperament.
Female, available
Female, available
TCRaised by Tammy C.
Clouser's Bodacious Danes & Miniature Schnauzers · 80 miles away from Florence, SC
We are proud to offer our Great Dane & Mini Schnauzer puppies to loving homes! Our dogs are healthy & have great temperaments.
3 owner reviews
Raised by Karmen U.
Underwood Danes AKC · 84 miles away from Florence, SC
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
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- CM
Raised by Christy M.
QC MOSS DANES · 84 miles away from Florence, SC
Having a dog in our lives is such a blessing. We find so much fulfillment in providing that same companionship to other homes!
- Kl
Raised by Kathy l.
Kwdanes · 84 miles away from Florence, SC
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
- TM
Raised by Tiffany M.
Infinity Danes · 84 miles away from Florence, SC
We are proud to offer our beautiful Great Dane puppies to loving homes! Our dogs are healthy and have great temperaments.
Scooby, dad
Velma, mom
THRaised by Tracey H.
Bonetown Great Danes · 84 miles away from Florence, SC
We love to responsibly raise and train our puppies so they have the tools to be well-rounded, beloved family members.
Toot, mom
Cino, dad
Raised by Brittany J.
Massive Creations · 84 miles away from Florence, SC
Our mission is to raise healthy, happy, adorable Great Dane puppies and connect loving families with their new best friend!
- BM
Raised by Brenda M.
Majestic Danes · 95 miles away from Florence, SC
Our dogs are our beloved companions. We care deeply about this breed and are proud to be responsible Great Dane breeders.
Lylah, mom
Enzo, dad
Raised by Kristy V.
Carolina Great Danes & Toy Poodles · 101 miles away from Florence, SC
Carolina Great Danes & Toy Poodles raises healthy, well-socialized puppies that bring years of joy to their forever families.
25 owner reviews
Baby, mom
Whisper, mom
Raised by Bonnie B.
Windy Knoll Great Danes · 101 miles away from Florence, SC
Please check with your housemates, spouse, partner or parents PRIOR to messaging. Payoff is due 1 week before pup goes home.
4 owner reviews
Raised by Jennifer N.
Newton's AKC Great Dane's · 116 miles away from Florence, SC
We raise our dogs with love in our home. We have high expectations for our pups and strive to put each one into a loving family.
Raised by Audrey B.
Azal Great Danes · 116 miles away from Florence, SC
The Great Dane breed is an exceptional breed that we love and cherish.
Raised by Heather S.
DSD Danes · 116 miles away from Florence, SC
Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.
Raised by Lisa H.
Selah Great Danes & Chinese Cresteds · 116 miles away from Florence, SC
The health of our dogs always comes first. We're committed to ethical breeding & a continued effort to enhance the breed standard.
Monte, dad
Bruna, mom
Raised by shannon J.
Tarheel danes · 116 miles away from Florence, SC
We’re devoted to ensuring there are healthy puppies for others to enjoy and we do so by responsibly growing this incredible breed.
- AA
Raised by Alyssa A.
TLC B & G KENNELZ · 116 miles away from Florence, SC
We’re devoted to ensuring there are healthy puppies for others to enjoy and we do so by responsibly growing this incredible breed.
Female, reserved
Raised by Lori R.
Gentle Giant Danes, LLC · 121 miles away from Florence, SC
We decided to start breeding to share the best possible puppies with excellent personalities, temperament, and most of all health!
- LM
Raised by Lori M.
LoriDanes Great Danes · 124 miles away from Florence, SC
I have had Great Danes for 25 years: have been involved in the AKC show world for about 10 years. 100% BRED to GDCA standards.
Raised by Treasure W.
Treasure Wylie · 131 miles away from Florence, SC
I produce pups that will continue to excel in their chosen field, whether that be working, showing, or as an active companion.
Male, reserved
Male, reserved
Raised by Caitlin L.
Pawlmetto Danes · 135 miles away from Florence, SC
We strive to pair the best Danes, to keep our bloodline pristine and in good health!
Female, reserved
Male, reserved
MMRaised by Meghan M.
Gentry Farm Danes · 138 miles away from Florence, SC
I breed Great Danes responsibly, prioritizing health, temperament, and lifelong success for each dog.
- KP
Raised by Karen P.
A20 Danes · 149 miles away from Florence, SC
Our dogs are our beloved companions. We care deeply about this breed and are proud to be responsible Great Dane breeders.
Raised by Misty M.
Misty Creek · 149 miles away from Florence, SC
We’re devoted to ensuring there are healthy puppies for others to enjoy and we do so by responsibly growing this incredible breed.
Male, reserved
Male, reserved
Raised by Maria M.
Divine Blue Angels Great Danes · 151 miles away from Florence, SC
Our mission is to bring amazing healthy Great Danes into the world to provide love and support.
Raised by Crystal B.
CAB Danes · 156 miles away from Florence, SC
I am a proud breeder of Great Danes focusing on quality, health, show, and companionship. I love my dogs and what I do.
Banner, dad
Blue, dad
JFRaised by Julia F.
Tar River Great Danes · 156 miles away from Florence, SC
We love to responsibly raise and train Great Danes so they have the tools to be well-rounded, beloved family members.
Female, available
Female, available
Raised by Susan A.
Allen’s Ridge Ranch · 157 miles away from Florence, SC
We offer top-quality pups from carefully planned litters. We focus on temperament, soundness,health, conformation, and longevity
Male, available
Raised by Alexis M.
Virginia Great Danes · 185 miles away from Florence, SC
We’re so excited to be able to help families experience the longtime loyalty of welcoming a new puppy into their lives!
Storm, mom
Raised by Stephanie C.
Tidal Wave Danes · 216 miles away from Florence, SC
We are devoted to raising Health Tested, quality AKC Great Danes.
Female, reserved
Maze, mom
Raised by Shena M.
North Cedar Danes · 228 miles away from Florence, SC
We strive to produce the best overall pet and family members. We focus on health, temperament and conformation.
6 owner reviews
Delilah, mom
LRRaised by Linnea R.
Duke and Duchess Danes · 229 miles away from Florence, SC
We work hard to produce healthy, well-rounded Great Dane puppies that will make others as happy as our dogs have made us!
Chronus, dad
June, mom
AERaised by Adam E.
Titans Legacy Danes · 229 miles away from Florence, SC
All of our dogs are loved as family members. We cherish our puppies from birth up until they leave our arms to snuggle into yours!
- BW
Raised by BJ W.
BJ's Great Danes · 229 miles away from Florence, SC
We breed high-quality Great Danes. We love what we do and are committed to producing well-bred, healthy puppies for loving homes.
- AC
Raised by Anita C.
Anita Chapman · 232 miles away from Florence, SC
I breed top-quality Dane puppies to the written standard. I produce top-quality companions. Dogs transform a house into a home!
Related breeds
Great Dane
Buyer’s Guide
Nationally, prices usually range from $2,000 to $3,000. While it may cost more up front, starting with a healthy puppy can help you avoid costly issues later. These ranges reflect the care behind responsible breeding and offer a reliable view of what ethical breeding really costs.
About the Great Dane
This dog is magnificent, combining great size and commanding appearance with a surprising amount of gentleness and, yes, goofiness. Learn more
Moderate Energy
Energy level
Minimal Maintenance
Grooming
Average Trainability
Trainability
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Frequently asked questions
What is the average cost of Great Dane puppies in Florence, SC?
Prices may vary based on the breeder and individual puppy for sale in Florence, SC. On Good Dog, Great Dane puppies in Florence, SC range in price from $1,600 to $2,600. We recommend speaking directly with your breeder to get a better idea of their price range.
Is Great Dane in Florence, SC a high shedding breed?
Great Dane puppies in Florence, SC are a moderate shedding breed. However, it's possible that a dog's level of shedding may vary by individual puppy.
How long do Great Dane puppies in Florence, SC live on average?
Great Dane puppies in Florence, SC may live on average between 7 to 10 years.
Do Great Dane need a lot of exercise in Florence, SC?
Great Dane puppies in Florence, SC tend to have moderate energy. Typically, dogs with a moderate energy level may require around 30 to 60 minutes per day of physical activity, though individual dogs may fall outside that range.
Can I adopt a Great Dane from a rescue or shelter?
On Good Dog, you can search for Great Dane puppies or dogs in rescues and shelters near Florence, SC. Adopting a Great Dane from a shelter or rescue in Florence, SC is generally less expensive than buying a puppy from a breeder with ethical practices. Across the United States, there are dedicated rescues that specialize in specific breeds and may even help transport a Great Dane dog to you in Florence, SC from another part of the country. Although it can be more cost-effective, adopting the exact breed you're looking for is typically more difficult than working with a responsible breeder. Learn more about adopting a dog from a shelter or rescue.
About Good Dog
About Good Dog
Good Dog is your trusted partner for finding Great Dane puppies for sale near Florence, SC. Our vetted network of responsible Great Dane breeders makes it easy to search listings, connect directly, and ask questions — all in one safe, protected place. Work directly with breeders you can trust and complete payments securely through Good Dog, so you can bring home your Great Dane puppy with confidence.