40+ Great Dane puppies for sale from ethical breeders near Florence, SC

Raised by Jennifer H.

Ocean Blue Danes · Drop-off to you

Producing quality black and blue Great Danes following the breed standard set forth by the Great Dane Club of America.

Raised by Dana M.

Vail Great Dane · Meet breeder for pickup

We are a passionate and dedicated breeding program that produces dogs with great obedience, conformation, and agility.

Raised by Emily P.

Phantasm Farms · Meet breeder for pickup

We are a small, intentional Great Dane breeder devoted to preserving the breed’s gentle nature, health, and structure.

Raised by Cindy C.

Absolute Sasdania · Meet breeder for pickup

We are huge animal lovers and have a special place in our hearts for our dogs. We want to provide top-quality beloved companions.

Raised by Sharon H.

Hladik Great Danes · Drop-off to you

We breed and show top-quality dogs. Our heavy involvement in the show world speaks to the standards that we breed our dogs by.

Raised by Morgan S.

LakeSide Danes · Drop-off to you

We offer top quality, loving and loyal family pets, focusing on temperament.

Raised by Laurie S.

Poke-A-Nose Danes · Drop-off to you

I love being a breeder. My focus is on raising structurally correct Great Dane puppies with excellent health and temperaments.

Raised by Lisa H.

Pocono Mountain Great Danes · Meet breeder for pickup

We love to responsibly raise and train our puppies so they have the tools to be well-rounded, beloved family members.

Raised by DAYSHA B.

Breken Great Danes · Drop-off to you

We are huge animal lovers and have a special place in our hearts for our dogs. We want to provide top-quality beloved companions.

Raised by Jessica R.

Florida Wrinkles · Drop-off to you

We’re devoted to ensuring there are healthy pups for others to enjoy.

Raised by Carmella J.

Carmella Jichetti · Meet breeder for pickup

We are experienced, reputable Great Dane breeders. We take great pride in our dogs, our puppies, and our program.

Raised by Jason S.

Alpine Great Danes · Drop-off to you

Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.

Raised by Clairessa S.

Beachside Kennels · Drop-off to you

We love to responsibly raise and train Great Danes so they have the tools to be well-rounded, beloved family members.

TC

Raised by Tamela C.

Twin Oaks Danes · Meet breeder for pickup

Having a pup in our lives is such a blessing. We find so much fulfillment in providing that same companionship to other homes!

PB

Raised by Pamela B.

Big Paw Great Danes · Meet breeder for pickup

We are committed to always responsibly breeding with the best interest of our puppies’ health and longevity at the forefront.

KB

Raised by Kayla B.

Kayla's Great Danes · Meet breeder for pickup

Our puppies are excellent representations of their breed, and we are proud to offer our high-quality puppies to loving homes.

SL

Raised by Stacy L.

Pink Star Danes and French Bulldogs · Drop-off to you

Many of our puppies have become exceptional show dogs, and all of them have become excellent family dogs and lifelong friends.

Raised by Joyel C.

Joyel's Great Danes · Meet breeder for pickup

We’re devoted to ensuring there are healthy puppies for others to enjoy and we do so by responsibly growing this incredible breed.

Raised by Samantha D.

The Great French ( Great Danes + Frenchies ) · Meet breeder for pickup

We focus on health, temperament & structure! All of our breeding dogs are raised in home, health tested, & have obedience titles.

Raised by Michael U.

F&B Kennels · Drop-off to you

Breeding Great Danes based on health, temperament, and longevity. Traditional and alternative colors, with traditional structure.

Raised by Carolyn B.

MommaDukes Danes · Drop-off to you

Breeding beautiful, healthy, structurly sound, smart puppies. Raised with love in our home for other families to love!

Raised by Prophecy D.

Prophecy Danes · Drop-off to you

We are lovers and breeders of quality purebred AKC Great Danes. We breed for health, temperament & longevity. They are our life!

Raised by Machelle M.

M&J Danes · Meet breeder for pickup

We love this breed and the experience of having litters! Our mission is to raise pups that are set to become the best companions.

Raised by Jayden M.

R&R Breeding and Pet Care · Drop-off to you

We are pet owners first and foremost. All of our puppies are raised as members of our family until they’re ready to join yours.

Raised by Heather W.

Genai Great Danes · Meet breeder for pickup

Our name, Genai, means "the one whom everyone loves." We love our Danes, and we hope you will too’

Raised by Michelle M.

De Leon Danes · Drop-off to you

My goal is to increase the longevity of Great Danes. My dogs are not bred for their color or height; they're bred for health.

Raised by Lisa F.

Above The Salt Danes · Meet breeder for pickup

We offer exceptional quality puppies for a variety of homes including pet, breeding, and service homes. Our dogs are our pride!

Raised by Bluestone V.

Bluestone Valley Great Danes · Meet 94 miles away from Florence, SC

Our dogs are bred for health, temperament, and conformation. We strive to produce quality pets that are true to breed standards.

PH

Raised by Pamela H.

House of Henry Great Danes 2 · Meet breeder for pickup

Our dogs are our beloved companions. We care deeply about this breed and are proud to be responsible Great Dane breeders.

Dm

Raised by Destiny m.

Moonstone Danes · Meet breeder for pickup

All of our dogs are loved as family members. We cherish our puppies from birth up until they leave our arms to snuggle into yours!

Raised by Kelsey F.

K.C. Kennels · Drop-off to you

We take great pride in breeding to produce pups that are the total package.

Raised by Jade I.

Gentle Giant Companions · Drop-off to you

We offer top quality Great Danes as pets, with a focus on health and temperament.

Raised by John & Mandy W.

Weslow AKC Danes · Drop-off to you

We are proud to offer our beautiful Great Dane puppies to loving homes! Our dogs are healthy and have great temperaments.

Raised by Amanda R.

Southern Beauty Danes · Meet breeder for pickup

We're new breeders starting a small program. We hope to help provide families with quality puppies as we continue to learn & grow!

SD

Raised by Sherry D.

Sherwood Mastiffs · Drop-off to you

We offer high-quality puppies. Our dogs are excellent representations of their breeds, and we are proud to continue their lines.

SR

Raised by Stephanie R.

Reagan’s Danes · Drop-off to you

Our dogs are bred for health, temperament, and intelligence. We strive to produce the best overall pets and family members.

Raised by Michelle C.

Campbell Great Danes · Drop-off to you

Puppies are raised in our home. They come from AKC champion bloodlines. Parent dogs are OFA tested. Puppies are AKC registered.

Raised by Megan T.

Megan Toeller · Meet breeder for pickup

Located in Memphis, TN, KDT Danes is a small preservation breeder with typically only 1 litter per year.

Raised by Lori H.

Waterfront Danes · Meet breeder for pickup

I offer top-quality Great Dane puppies for families who share the same love and passion that I do for these lovely companions.

Raised by Rebeka B.

Alchemy Danes · Meet breeder for pickup

We at Alchemy Danes strive for the health and longevity of the Great Dane Breed. Our dogs and puppies are our pride and joy!

Raised by Emily H.

North Park Great Danes · Drop-off to you

We are a preservation breeding program that only has a litter every few years.We breed for health, temperament, and conformation.

Raised by Natalie L.

RP DANES · Drop-off to you

Pups will come with -AKC papers -Vaccines -microchip -dewormed